Blar i forfatter "Meen, Astri Jeanette"

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    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-07)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to ...

    • Serglycin in Quiescent and Proliferating Primary Endothelial Cells 

      Reine, Trine M.; Vuong, Tram Thu; Rutkovskiy, Arkady; Meen, Astri Jeanette; Vaage, Ingvar Jarle; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-22)
      Proteoglycans are fundamental components of the endothelial barrier, but the functions of the proteoglycan serglycin in endothelium are less described. Our aim was to describe the roles of serglycin in processes relevant for endothelial dysfunction. Primary human umbilical vein endothelial cells (HUVEC) were cultured in vitro and the expression of proteoglycans was investigated. Dense cell ...

    • Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GRO alpha/CXCL1 

      Meen, Astri Jeanette; Øynebråten, Inger; Reine, Trine M.; Duelli, Annette; Svennevig, Katja Christiane; Pejler, Gunnar; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-01-28)
      Proteoglycan (PG) expression was studied in primary human umbilical vein endothelial cells (HUVEC). RT-PCR analyses showed that the expression of the PG serglycin core protein was much higher than that of the extracellular matrix PG decorin and the cell surface PG syndecan-1. PG biosynthesis was further studied by biosynthetic [<sup>35</sup>S]sulfate labeling of polarized HUVEC. Interestingly, ...

    • Serglycin is part of the secretory repertoire of LPS-activated monocytes 

      Kolseth, Ingrid Moss; Reine, Trine M.; Vuong, Tram Thu; Meen, Astri Jeanette; Fan, Qiong; Jenssen, Trond Geir; Grønning-Wang, Line Mariann; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-11)
      Monocytes play multiple roles in the immune system, and are active in both acute and chronic diseases. Patients exposed to bacterial infections depend on monocytes in defense reactions, but excessive immune reactions may also cause morbidity through systemic inflammatory responses. Few studies have addressed the importance of proteoglycans, and in particular, the hematopoietic serglycin, in such ...